WebConnective tissue growth factor (CTGF), also termed fisp12, β IG-M2, and IGF-BP8, is a secreted cysteine-rich growth factor that belongs to the CCN (cyr61, CTGF, nov) family. … WebJan 12, 2011 · San Francisco, CA - January 12, 2011. FibroGen, Inc. today announced initiation of an open-label phase 2 study to evaluate the safety, tolerability, and efficacy of FG-3019, a human monoclonal antibody against connective tissue growth factor (CTGF), in individuals with idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fatal lung …
CTGF is a central mediator of tissue remodeling and …
WebFG-3019 is a fully human monoclonal antibody specific for CTGF. Pre-clinical studies suggest that FG-3019 penetrates into tissues to reduce effective tissue levels of CTGF … WebCTGF and human anti-human antibodies (HAHA) levels. Plasma was obtained for pharmacokinetic (PK) analyses pre- and post FG-3019 infusions. FG-3019 exposure and plasma CTGF at baseline were correlated with clinical progression and survival outcomes. Assessments of CTGF were limited to baseline values, since subsequent billy\u0027s seafood tierra verde
CTGF Antibody (E-5) SCBT - Santa Cruz Biotechnology
WebJun 22, 2006 · FG-3019 is an investigational fully human monoclonal antibody against CTGF. In a phase 1 study of FG-3019 in patients with idiopathic pulmonary fibrosis, FG-3019 was found safe and well tolerated. Currently, FG-3019 is the subject of a phase 1b study in diabetic patients with incipient nephropathy. WebMonoclonal Antibody for studying CTGF. Cited in 36 publications. Validated for Western Blotting, Immunofluorescence (Immunocytochemistry). Highly specific and rigorously validated in-house, CTGF (D8Z8U) Rabbit … WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the … cynthia howell alpha kappa alpha