Oxysterol-binding protein-related protein 3b

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August undefined, 2024

WebMay 15, 2024 · The oxysterol binding protein (OSBP) is a storied protein in organelle biology. Its early roles include acting as a membrane contact site (MCS) tether as well as a lipid antiporter. A surprising new function for OSBP in MCS dynamics has now been uncovered in a recent study by Jamecna et al. (Dev. Cell 2024;49:220–234). WebSymbol Description Category UniProt ID GIFtS GC id Score; 751: NKX2-2: NK2 Homeobox 2: Protein Coding: O95096: 47: GC20M021511: 0.39: 752: NR2C1: Nuclear Receptor Subfamily 2 Group C Member 1

OSBP-related proteins: lipid sensors or transporters?

WebThe OSBP-related protein family Protein families displaying sequence homology to the carboxy-terminal sterol-binding domain of oxysterol-binding protein (OSBP; denoted OSBP-related ligand-binding domain [ORD]) are present in practically all eukaryotic organisms [1]. In humans [2,3], as well as in mice [4], the gene is there dust in rain

The targeting of the oxysterol-binding protein ORP3a to

WebApr 6, 2024 · The blue fluorescent protein (BFP) was cloned from the pLVX-BFP plasmid. The PH domain of oxysterol-binding protein (OSBP) and human heat shock protein family A member 5 (HSPA5) gene were cloned from the THP-1-cell cDNA library. ... (Figure 3b). HSPA5 is a member of the heat shock protein 70 (HSP70) family and localizes to the ER … WebNational Center for Biotechnology Information WebMay 17, 2024 · Oxysterol-binding protein-like 2 (OSBPL2), also known as oxysterol-binding protein-related protein (ORP) 2, is a member of lipid transfer protein well-known for its … is the reduvia good

Role of oxysterol-binding protein-related proteins in

Oxysterol-binding proteins: Sterol and phosphoinositide sensors ...

Web3.5 Sterol-transfer protein, Osh4. The oxysterol-binding protein-related proteins (Orp) are conserved from yeast to humans and are implicated in the regulation of sterol … WebB IBLIOGRAPHY - by the human oxysterol-binding protein (OSBP) Loading... Home Other. B IBLIOGRAPHY ... (BMP), but Not 3,1’-BMP, Increases Membrane Curvature Stress to Enhance α-Tocopherol Transfer Protein Binding to Membranes. Lipids 2015, 50 (3), 323–328. is there dutch bros in seattleWebDec 5, 2024 · Abstract. Oxysterol-binding protein-related proteins (ORPs) are a conserved class of lipid transfer proteins that are closely involved in multiple cellular processes in … is the red wave already crashing

"WebFeb 14, 2024 · Oxysterols accumulate in tissues and exert pharmacologic effects on cellular sterol biosynthesis and uptake. They are oxidized byproducts of cholesterol that cause cytotoxic effects on a variety of cells. Oxysterol-binding proteins such as OSBP1 ( 167040) and OSBP2 may mediate oxysterol cytotoxicity in tissues (summary by Moreira et al., … " - Oxysterol-binding protein-related protein 3b

Oxysterol-binding protein-related protein 3b

WebOct 1, 2013 · Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute a family of sterol and phosphoinositide binding proteins conserved in eukaryotes. The mechanisms of ORP function have remained incompletely understood. WebJul 24, 2015 · We found that two similar ER integral membrane proteins, oxysterol-binding protein (OSBP)–related protein 5 (ORP5) and ORP8, tethered the ER to the plasma membrane (PM) via the interaction of their pleckstrin homology domains with phosphatidylinositol 4-phosphate (PI4P) in this membrane.

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WebMar 1, 2001 · Oxysterol-binding protein-related protein 3 Short names ORP-3; OSBP-related protein 3 Gene names Name OSBPL3 Synonyms KIAA0704, ORP3, OSBP3 Organism names Organism Homo sapiens (Human) Taxonomic identifier 9606 NCBI Taxonomic lineage WebID: OSBL1_MOUSE DESCRIPTION: RecName: Full=Oxysterol-binding protein-related protein 1; Short=ORP-1; Short=OSBP-related protein 1; FUNCTION: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional …

http://cjbmb.bjmu.edu.cn/EN/10.13865/j.cnki.cjbmb.2024.08.03 WebThe oxysterol-binding protein-related proteins (Orp) are conserved from yeast to humans and are implicated in the regulation of sterol homeostasis and in signal transduction …

WebApr 10, 2024 · Lipid transfer proteins in the Sec14 and oxysterol-binding protein (OSBP)-related protein (ORP) families, which have well-defined lids to their hydrophobic cavities and bind phospholipids tail-first [14, 47], similarly exhibit conformational changes upon membrane binding that displace the lids to their hydrophobic cavities as required for lipid ... WebGene ID: 104893668, updated on 20-Jun-2024. Summary Other designations. oxysterol-binding protein-related protein 3B

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WebAug 3, 2024 · Abstract Oxysterol-binding protein (OSBP) is a non-vesicular transport protein that exists and participates in the metabolism of lipids and sterols in eukaryotic cells. OSBP is known as the oxysterol-binding protein-related protein (ORP) in mammals and oxysterol-binding protein homologues (OSH) in yeasts. ikea billy bookcase blesserhouseWebMar 4, 2005 · Oxysterol-binding protein (OSBP) is the founding member of a family of sterol-binding proteins implicated in vesicle transport, lipid metabolism, and signal transduction. Here, OSBP was found to function as a cholesterol-binding scaffolding protein coordinating the activity of two phosphatases to control the extracellular signal–regulated ... ikea billy bookcase anchor to wallSeveral structural features and functional domains have been identified within the … 1.. IntroductionOxysterol-binding protein (OSBP) is a high-affinity receptor protein … In contrast to fungal and mammalian cells, where oxysterol-binding proteins are … The hyd1 mutant is phenotypically similar to fk (Figure 2) and was predicted to be … Analyses of deletion mutants of OSBP revealed that the carboxy-terminal half of … Proteins with sequence homology to the carboxy-terminal ligand binding domain … Cellulose is the major load-bearing and omnipresent polysaccharide in the … Sterol was the name originally proposed to describe a 3β-monohydroxy compound … Kes1p shares homology with human oxysterol binding protein and participates … The isolation of a gene from Saccharomyces cerevisiae, SWH1, with a … ikea billy bookcase black-brown glass doorsWebThe present invention discloses agents and methods for inducing osteoblastic cellular differentiation, as well as the use of such agents and methods to treat patients to maintain bone mass, enhance bone formation and/or bone repair. Exemplary agents include oxysterols, alone or in combination with particular oxysterols, or other agents, such as … is there dvr with sling tvWebApr 13, 2024 · Sterols are present in eukaryotic membranes and significantly affect membrane fluidity, permeability, and microdomain formation. They are synthesized in the endoplasmic reticulum (ER) and transported to other organelles and the plasma membrane. Sterols play important roles in the biogenesis and maintenance of mitochondrial … ikea billy bookcase as built insWebFirst, oxysterol-binding protein like protein 3 (OSBPL3), the closest gene to rs10282247, encodes oxysterol-binding-related protein (ORP) 3 that serves as lipid transporters and manages cellular lipid metabolism. ... and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid-like 3B. Cancer Sci. 2024;111(7) ... is the red wave happeningWebMar 14, 2024 · Oxysterol-binding protein (OSBP) and OSBP-related protein 4 (ORP4) have emerged as potentially druggable targets in antiviral and precision cancer drug development. Multiple structurally diverse small molecules function through targeting the OSBP/ORP family of proteins, including the antiviral steroidal compounds OSW-1 and T-00127-HEV2. … is the red wii backwards compatible